1. Aging Methods and Protocols. Ed. Y. A. Barnett and C. R. Barnett;
2000
2. Alzheimer's Disease: Advances in Etiology, Pathogenesis and Therapeutics.
Edited by Khalid Iqbal, Sangram S.Sisodia and Bengt Winblad; 2001
3. Alzheimer's Disease: Methods and Protocols. Ed. Hooper, Nigel M; 1999
4. American Medical Encyclopedia. v1.0 2002
5. Apoptosis in Neurobiology. Yusuf A Hannun , Rose-Mary Boustany; 1998
6. Atlas of Functional Neuroanatomy. Walter Hendelman; 2000
7. Brain Facts, Fourth edition. Society for Neuroscience; 2002
8. CNS injuries: Cellular Responses and Pharmacological Strategies. Martin
Berry, Ann Logan; 1999
9. Color Atlas and Textbook of Human Anatomy. Vol. 3. Nervous System and
Sensory Organs. Kahle W., Leonhardt H., Platzer W.; 1986
10. Culture and Psychotherapy: a guide to clinical practice. Ed. Wen-Shing
Tseng, Jon Streltzer; 2001
11. Current Protocols in Neuroscience. Ed. Jacqueline N. Crawley; Charles
R. Gerfen; Michael A. Rogawski; David R. Sibley; Phil Skolnick; Susan Wray;
2003
12. Differentiation of Embryonic Stem Cells. Ed. Paul M. Wassarman; 2003
13. Drugs of Abuse, Neurological Reviews and Protocols. Ed. Wang, John
Q.; 2002
14. Embryonic Stem Cells: Methods and Protocols. Ed. K. Turksen; 2001
15. Glossary of Molecular Biology Terminology. Kenneth Kaushansky,; 2001
16. Handbook of Neuroprosthetic Methods. Ed. Warren E.Finn, P.G.LoPresti;
2003
17. Influence of Stress on Cell Growth and Product Formation. 2000
18. Methods in Genomic Neuroscience. Hemin R Chin, Steven O Moldin; 2001
19. Methods of Behavior Analysis in Neuroscience. Jerry J Buccafusco;
2000
20. Molecular Neuroscience. Patricia Revest, A. Longstaff; 1997
21. Neural Stem Cells: Methods and Protocols. Ed. T. Zigova, P. R. Sanberg,
and J. R. Sanchez-Ramos; 2002
22. Neuroanatomy: An Atlas of Structures, Sections, and Systems. 6th Edition
Duane E. Haines; 2003
23. Neurobiology of Aggression, Understanding and Preventing Violence.
Mattson, Mark P; 2003
24. Neurodegeneration Methods and Protocols. Ed. Harry, Jean; Tilson,
Hugh A.; 1998
25. Neurogenetics, Methods and Protocols. Ed. Potter, Nicholas T.; 2002
26. Neuroinflammation Mechanisms and Management, 2nd ed. Wood, Paul
L.; 2002
27. Neurological Foundations of Cognitive Neuroscience. Mark D'Esposito;
2002
28. Neuropeptide Protocols. Ed. Irvine, G. Brent; Williams, Carvell H.;
1996
29. Neuropeptide Y Protocols. Ed. Balasubramaniam, Ambikaipakan; 2000
30. Neuropharmacology Methods in Epilepsy Research. Steven L Peterson,
Timothy E Albertson; 1998
31. Neurotransmitter Methods. Ed. Rayne, Richard C.; 1997
32. Neurotransmitters and Neuromodulators: Handbook of Receptors and Biological
Effects. Oliver von Bohlen und Halbach, Rolf Dermietzel; 2002
33. Neurotransmitters, Drugs and Brain Function. Ed. Roy Webster; 2001
34. Neurotrophin Protocols. Ed. Rush, Robert A.; 2000
35. New Concepts in Cerebral Ischemia. Rick C. S. Lin; 2001
36. Nicotinic Receptors in the Nervous System. Edward D Levin; 2001
37. NMDA Receptor Protocols. Ed. Li, Min; 1999
38. Opioid Research: Methods and Protocols. Ed. Pan, Zhizhong Z.; 2003
39. p53 Protocols Ed. Deb, Sumitra; Deb, Swati Palit; 2003
40. Parkinson's Disease Methods and Protocols. Ed. Mouradian, M. Maral;
2001
41. Pathogenesis of Neurodegenerative Disorders. Mattson, Mark P.; 2001
42. Phospholipid Signaling Protocols . Ed. Bird, Ian; 1998
43. Protocol for Neural Cell Culture (3rd Edition). Ed. S.Fedoroff, A.Richardson;
2001
44. Psychiatric Genetics: Methods and Reviews. Ed. Leboyer, Marion; Bellivier,
Frank; 2002
45. Psychiatry as a Neuroscience. Ed. Juan Jos, Lpez-Ibor, Wolfgang Gaebel,
Mario Maj, Norman Sartorius; 2002
46. Psychiatry in Society. Ed. Norman Sartorius, Wolfgang Gaebel, Juan
Jos? L?pez-Ibor, Mario Maj; 2002
47. Signal Transduction . Bastien Gomperts, Ijsbrand Kramer, Peter Tatham;
2002
48. Signal Transduction and Human Disease. Ed. Toren Finkel, J. Silvio
Gutkind; 2003
49. Signal Transduction Protocols. Ed. Kendall, David A.; Hill, Stephen
J.; 1995
50. Signaling Molecules: Roles in Differentiation and Proliferation
51. Signaling Networks and Cell Cycle Control. The Molecular Basis of Cancer
and Other Diseases Ed. IJ.S.Gutkind; 2000
52. Stem Cell Biology. Ed. D.R.Marshak, R.L.Gardner, D.Gottib; 2001
53. Stem Cell Biology and Gene Therapy . Ed. P.J.Quesenbberry, G.S.Stein,
B.G. Forget, S.M.Weisman; 1998
54. Stem Cells. Ed. C.Potten; 1996
55. Stem Cells and the Future of Regenerative Medicine . Committee on
the Biological and Biomedical Applications of Stem Cell Research; 2002
56. Stem Cells: Scientific Progress and Future Research Directions. Dir.
Ruth Kirschstein, M.D., Lana R. Skirboll; 2001
57. Stress Response, Methods and Protocols. Ed. Keyse, Stephen M.; 2000
58. Suicide Gene Therapy: Methods and Reviews. Ed. Springer, Caroline
J.; 2003
59. The MIT Encyclopedia of the Cognitive Sciences. Ed. R.A. Wilson,
F.C. Keil; 1999
60. The Neuronal Environment, Brain Homeostasis in Health and Disease.
2001
61. The Neurophysics of Human Behavior: Explorations at the Interface of
the Brain, Mind, Behavior, and Information. Mark E Furman, Fred P Gallo;
2000
62. Theoretical Neuroscience. Peter Dayan, LF Abbott; 2001
63. Treatment of Recurrent Depression. Ed. John F. Greden; 2001
64. Wiley Encyclopedia of Molecular Medicine, Volumes 1-5 Edited by
John Wiley & Sons, Inc.; 2002
65. Нейробиология: в 2-х т. Т.1. Шеперд Г., Мир; 1987; 454 с.
66. Нейробиология: в 2-х т. Т.2. Шеперд Г., Мир; 1987; 368 с.
67. Нейрохимия. Под ред. И.П. Ашмарина. Изд. Института биомедицинской
химии; 1996; 470 с.
68. Нейрохимия. Под ред. М.И.Прохоровой. Изд. Ленингр. ун-та; 1979;
pp267
69. Нейрохимия: Основы и принципы. Хухо Ф. Мир; 1990; 384с.
70. Основы нейрофизиологии: Учебное пособие. Шульговский В.В. Аспект
Пресс; 2000; pp277
71. От нейрона к мозгу. MS Word вариант. Николлс Джон, Мартин Роберт,
Валлас Брюс, Фукс Пол. Едиториал УРСС; 2003; pp672
72. Психогенетика. Под ред. И. В. Равич-Щербо. Аспект Пресс; 2000; pp447
Пособие для научных работников по развитию навыков устной речи
С.М. Костенко, И.Б. Борковская, Т.Н. Михельсон, Н.В. Успенская
Наука; 1988; pp151; ISBN: 5020279404
Предлагаемое пособие предназначено для развития навыков устной речи в группах
аспирантов и научных сотрудников, готовящихся к сдаче кандидатского экзамена
по английскому языку и при работе в студенческих группах.
Aging Methods and Protocols
Ed. Y. A. Barnett and C. R. Barnett
Humana Press; 2000; pp400; ISBN: 0-89603-582-4
Methods in Molecular Medicine, vol.38
Yvonne and Christopher Barnett and a team of recognized international experts
detail key biochemical, analytical, and molecular techniques for the investigation
of aging at the cellular, tissue, organ, and whole system levels. These
cutting-edge methods address a wide range of research needs, from uncovering
the factors associated with cell senescence and death, to exploring alterations
in the body's ability both to metabolize xenobiotics and to defend itself
against biomolecular damage. State-of-the-art protocols also measure the
morphological, functional, and molecular changes that accumulate within
mitochrondria over time, and permit the genetic and functional characteristics
of the immune system to be determined. Wide ranging and highly practical,
Aging Methods and Protocols provides today's molecular gerontologists, pharmacologists,
and clinical investigators with a gold-standard collection of readily reproducible
techniques for identifying those key cellular and molecular processes that
might one day make it possible to regulate the aging process.
Alzheimer's Disease: Advances in Etiology, Pathogenesis and Therapeutics
Edited by Khalid Iqbal, Sangram S.Sisodia and Bengt Winblad
John Wiley & Sons; 2001; pp888; ISBN: 0471521760
Alzheimer's Disease is an ever-present problem affecting millions of people
around the world and, as people's average lifespan lengthens, its prevalence
is set to increase. A global effort is needed to combat the disease, including
research to investigate the causes, development of effective treatments
and, ultimately, prevention of the disease. Published every two years, these
timely books discuss the very latest research. This new volume in the series:
Provides a uniques source of reference to the important work being done
in this field
Gives academics and clinicians an opportunity to learn about cutting
edge developments
Covers all aspects of Alzheimer's Disease, including diagnosis, clinical
course, epidemiological course and therapeutics and disease mechanisms.
Alzheimer's Disease: Advances in Etiology, Pathogenesis and Therapeutics
and Therapeutics will provide essential information for basic and clinical
researchers in Alzheimer's Disease and other dementias as well as for those
who care for patients.
Alzheimer's Disease: Methods and Protocols
Ed. Hooper, Nigel M
Humana Press; 1999; pp424; ISBN: 1592591957
Methods in Molecular Medicine, vol.32
A panel of highly skilled investigators describe in detail their state-of-the-art
biochemical, cell biological, and molecular biological techniques for studying
the molecular basis of Alzheimer's disease. These readily reproducible,
step-by-step methods focus on work with the amyloid precursor protein and
the amyloidogenic peptide A?, but also include-with the recent identification
of presenilin proteins-techniques for determining the structure and biological
function of these proteins. In addition, there are chapters covering the
tau protein and its role in Alzheimer's disease, as well as an introductory
discussion of the history of the disease, its genetic basis, and the currently
available and possible future therapeutic agents. Cutting-edge and wide
ranging, Alzheimer's Disease: Methods and Protocols provides ready access
to proven, reproducible methods for elucidating the molecular basis of this
most common senile dementia.
American Medical Encyclopedia v1.0
Computer program with crack
Neologic Software; 2002
Apoptosis in Neurobiology
Yusuf A Hannun , Rose-Mary Boustany
CRC Press; 1998; pp286; ISBN: 0849333520
Provides ready access to the various methods currently used in the study
and evaluation of apoptosis
Discusses the significance, utility, and interpretation of methods and
approaches
Provides background information for each approach to help scientists
determine the relevancy of apoptosis to their research
The rapid growth of the study of apoptosis-mechanism-driven, regulated
cell death-has created an urgent need for reliable documentation of the
different approaches to and methods of studying the various aspects of the
field. Apoptosis in Neurobiology is an important resource for researchers
in this emerging frontier of biomedical study. This volume allows the uninitiated
neuroscientist intellectual and practical access to the study of apoptosis,
with special consideration to the nervous system. The first section concentrates
on conceptual approaches to the study of apoptosis in neurobiology and its
significance to the nervous system. The second section provides a user-friendly
approach to methods and techniques in the study of apoptosis as applied
to neurobiology.
Atlas of Functional Neuroanatomy
Walter Hendelman
CRC Press; 2000; pp280; ISBN: 0849311772
Offers explanatory text for all illustrations
Includes color and radiographic material to help visualize the CNS
Presents a unique set of illustrations of the limbic system
Accompanying CD-ROM contains all of the illustrations from the print
version, with the advantage of 3-D visualization and full color
The Atlas of Functional Neuroanatomy guides the student and practitioner
in visualizing and understanding the many parts of the central nervous system
(CNS)-the key to knowing where diseases occur. The illustrations include
photographs and drawings (some color-enhanced) which have been selectively
labeled; each is accompanied by text which explains the structures named
and appropriate clinically-relevant comments.
The Atlas presents an overview of the nervous system, followed by the sensory
and motor systems as they traverse the CNS. These features prepare students
to work through the localization process. The atlas also offers a detailed
look at the microanatomy, particularly of the brainstem. Radiographic images
are also included, along with illustrations of the blood supply of the brain.
The final section features a unique set of illustrations, and these serve
as the foundation for an integrated view of the structure and function of
the limbic system. The accompanying CD-ROM contains all the illustrations
from the print version, with the advantage of 3-D visualization and full
color. Most noteworthy are the pathways of the spinal cord and brainstem,
and the detailed illustrations of the microanatomy of the brainstem, along
with color sections of the human brainstem. All of this enables students
to approach the diseases of the nervous system with a strong anatomical background.
Brain Facts, Fourth edition
Society for Neuroscience
Society for Neuroscience; 2002; pp58; ISBN: 0-916110-00-1
Brain Facts is a 52-page primer on the brain and nervous system, published
by the Society for Neuroscience. In addition to serving as a starting point
for a lay audience interested in neuroscience, the book is used at the annual
Brain Bee, which is held in conjunction with Brain Awareness Week.
This newly revised edition of Brain Facts is available in print and in
pdf format. The new edition updates all sections and includes new information
on brain development, addiction, neurological and psychiatric illnesses
and potential therapies.
CNS injuries: Cellular Responses and Pharmacological Strategies
Martin Berry, Ann Logan
CRC Press; 1999; pp240; ISBN: 0849383099
Appraises pharmacological strategies for cytokine and growth-factor modulation
of essential components of injury response
Reviews cellular trafficking, limitation of cellular damage, and modern
techniques for the delivery of reagent
Examines glial, neuronal, macrophage, vascular, and immune responses
after CNS injury
Offers multidisciplinary coverage regarding CNS damage for a wide range
of disciplines
The basic science of the cellular and molecular responses of the brain
to injury is a rapidly expanding area of research that provides evidence
of growing opportunities for pharmacological intervention in the clinic.
CNS Injuries: Cellular Responses and Pharmacological Strategies is an up-to-date
examination of new developments in our understanding of the cellular and
trophic responses to CNS injuries and the potential treatment. This text
collates reviews of the most important areas of study regarding injury response
including
o inflammatory and immune reactions
o scarring
o neuron death
o demyelination and remyelination
o axonal regeneration
o re-establishment of neuronal connectivity
Providing a record of recent advances that will help point the way to future
developments, this enlightening reference is sure to benefit researchers
and practitioners in a broad range of disciplines, including: neurology,
pharmacology, pathology, toxicology, immunology, and many others.
Color Atlas and Textbook of Human Anatomy. Vol. 2. Internal Organs
Kahle W., Leonhardt H., Platzer W.
Thieme Medical Publishers; 1986; pp386; ISBN: 0865774846
A well-balanced combination of a full-fledged anatomic atlas and textbook,
eminently useful to students and medical practitioners alike. Skillful visual
approach to anatomy, which is a must in every physician's education, is
happily wedded to a lucid text juxtaposed page by page with magnificent
multicolor illustrations in such a manner that the concise description of
the functional aspects of anatomy provides a useful guide for the perceptive
student. Aspects of physiology and biochemistry are included to the extent
they have a bearing on the material presented.
Culture and Psychotherapy: a guide to clinical practice
Ed. Wen-Shing Tseng, Jon Streltzer
American Psychiatric Publishing; 2001; pp320; ISBN: 0880489553
Cultural diversity has always been a fact of life, nowhere more so than
in the unique melting pot of U.S. society. Respecting and understanding that
diversity is an important - and challenging - goals. Culture and Psychotherapy:
A Guide to Clinical Practice brings us closer to that goal by offering a
fresh perspective on how to bring an understanding of cultural diversity
to the practice of psychotherapy to improve treatment outcomes.
This remarkable work presents the nuts and bolts of incorporating culture
into therapy, in a way that is immediately useful and practical. Illustrated
by numerous case studies that demonstrate issues, techniques, and recommendations,
the topics in this wide-ranging volume focus not on specific race or ethnicity
but instead on culture.
Introduction - Summarizes the influence of culture (an abstract concept
defined as an entity apart from race, ethnicity, or minority) on the practice
and process of psychotherapy while offering a broadened definition of psychotherapy
as a special practice involving a designated healer (or therapist) and identified
client (or patient) to solve a client’s problem or promote a client’s mental
health
Case Presentations and Analysis - Illustrates distinctive cultural issues
and overtones within psychotherapy, such as the traditional Japanese respect
for authority figures, the Native American concept of spirit songs, the
clash of modern values with traditional Islamic codes, and the effects of
the conflict between Eastern values of dependence and group harmony and
Western values of independence and autonomy
Specific Issues in Therapy - Discusses lessons from folk healing, the
cultural aspects of the therapist-patient relationship, and the giving and
receiving of medication as part of therapy
Treating Special Populations - Presents issues and trauma faced by African
Americans, Hispanic veterans, Southeast Asian refugees, adolescents, and
the ethnic minority elderly
Special Models of Therapy - Shows the interplay between cultural issues
and specific models of therapy, including marital therapy for intercultural
couples and group therapy with multiethnic members
The relevance of cultural diversity will only grow stronger in the coming
years as our definition of community expands to embrace global - not just
local - issues. With its balanced combination of clinical guidance and conceptual
discussion highlighted by fascinating case studies, this volume, authored
by national and international experts, offers psychotherapists, psychiatrists,
psychologists, psychiatric residents, psychiatric nurses, and mental health
social workers - both in the U.S. and abroad - an expansive focus and richness
of content unmatched elsewhere in the literature.
Current Protocols in Neuroscience
Ed. Jacqueline N. Crawley; Charles R. Gerfen; Michael A. Rogawski; David
R. Sibley; Phil Skolnick; Susan Wray
John Wiley & Sons; 2003; ISBN: 0471163619
Current Protocols in Neuroscience (CPN) draws from techniques in molecular
neurobiology, neurophysiology, neuroanatomy, neuropharmacology, and behavioral
neuroscience to meet the specific needs of researchers in the full range
of disciplines that is involved in studying the brain, nervous system, and
corresponding behaviors. The editorial board of CPN have assembled an outstanding
range of methods to enable users to explore their fields in greater depth
and branch into related areas. The one-volume, looseleaf manual features
carefully edited techniques with authors troubleshooting tips and helpful
comments that come from extensive experience in using these procedures.
Differentiation of Embryonic Stem Cells
Ed. Paul M. Wassarman
Academic Press (now a part of Elsevier Science); 2003; pp509; ISBN: 0121822680
Methods in Enzymology, vol. 365
Since their isolation over twenty years ago, embryonic stem (ES) cells
have come to play a prominent role in many different fields in biomedical
research. While used extensively for gene targeting studies for the generation
of ‘‘knock-out mice,’’ it is their capacity to differentiate into a wide
array of lineages in culture that has most recently captured the attention
of basic scientists, clinical researchers, and the lay public. The capacity
of an ES cell to differentiate into almost any cell type in a culture dish
offers unprecedented opportunities for studies in lineage commitment and
development, gene function, and cancer. In addition, the development of
human ES cells in 1998 has expanded the potential uses of the in vitro differentiation
approach to include the generation of specific cell types for cell replacement
therapy and regenerative medicine.
It has been known for some time that mouse ES cells can differentiate in
culture and generate derivatives of the three primary germ cell layers:
ectoderm, endoderm, and mesoderm. In many of these early studies, however,
differentiation was not well controlled and the cultures often consisted
of mixtures of tissues. Significant advances in the methodologies of ES
cell differentiation have been made in recent years, and it is now possible
to generate relatively pure populations of cells from a number of different
lineages in a reproducible fashion. These new approaches have enabled investigators
to begin to use the system to probe the molecular events regulating early
lineage commitment, as well as to generate populations appropriate for cell
replacement therapy in preclinical models. With the establishment of human
ES cells, the challenge for those in the field of stem cell and developmental
biology is to now translate the information from the mouse to the human
system.
In this volume, we have brought together a comprehensive collection of
the most up-to-date methods for the differentiation of both mouse and human
ES cells into a broad spectrum of lineages. Together with the differentiation
protocols, we have solicited a select set of protocols that highlight approaches
for gene discovery and lineage selection using ES cells.
The chapters are written by leaders in the field from the international
community and provide technical details that will enable the reader to establish
and maintain ES cell cultures and induce their differentiation into a large
number of different lineages.
Drugs of Abuse, Neurological Reviews and Protocols
Ed. Wang, John Q.
Humana Press; 2002; pp528; ISBN: 1592593585
Methods in Molecular Medicine, vol.79
A cutting-edge collection of updated and core techniques for the neurological
study of drugs of abuse. Described in step-by-step detail by hands-on experts,
these readily reproducible protocols cover a wide variety of coherent methods
for gathering information on quantitative changes in protein and mRNA at
both tissue and cellular levels. There are various methods for detecting
single and multiple alterations in single and multiple gene expression, for
analyzing the functional roles of genes and proteins, for studying the release
kinetics of striatal dopamine, and for the quantitative measurement of such
neurotransmitters as acetylcholine. Insightful review articles address key
current topics on the effect of drugs of abuse on the brain.
Embryonic Stem Cells: Methods and Protocols
Ed. K. Turksen
Humana Press; 2001; pp512; ISBN: 0896038815
Methods in Molecular Biology, vol.185
Kursad Turksen and a panel of international experts describe their most
productive methods for using embryonic stem (ES) cells as in vitro developmental
models for many cell and tissue types. Set out in step-by-step detail, these
protocols range widely from ES cell isolation, maintenance, and modulation
of gene expression, to cutting-edge techniques that use cDNA arrays in gene
expression analysis and phage display libraries, the generation of antibodies
against very rare antigens, and the identification of and characterization
of protein and protein interactions. Embryonic Stem Cells: Methods and Protocols
will prove an invaluable resource not only for those interested generally
in cell and developmental biology, but also for those actively using, or planning
to use ES cells, to study fate choices and specific lineages.
Glossary of Molecular Biology Terminology
Kenneth Kaushansky,
Hematology 2001; pp20
Handbook of Neuroprosthetic Methods
Ed. Warren E.Finn, P.G.LoPresti
CRC Press; 2003; pp456; ISBN: 0849311004
The Biomedical Engineering Series, vol.7
Deals with emerging technologies like integration of MEMS with microelectronics
and biomolecular electronics technology
Provides a brief overview of three major areas in which research is highly
active in this field: hearing, vision, and motor prostheses
Comprehensively reviews available computer packages in the field and
where they can be found
Provides examples of neuroprosthetic systems at different stages of development,
from the more mature cochlear implant to the maturing areas of upper-limb
and motor control to the relatively fledgling area of visual prostheses
Work in the field of neuroprosthetics requires multidisciplinary teams,
but these collaborators must meet on common ground to develop an understanding
of the capabilities and limitations of each part of a bioengineering project.
The Handbook of Neuroprosthetic Methods provides a comprehensive resource
for the techniques, methodologies, and options available to properly design
and undertake experiments within the field of neuroprosthetics. It combines
the most commonly employed concepts, applications, and knowledge from the
many disciplines associated with neuroprosthetic research to foster more
effective, profitable, and productive collaborations.
From basic neurophysiology to emerging technologies, this book provides
a clear introduction to the entire range of neuroprosthetic systems. Each
chapter includes background information, methodology, illustrative figures
that clarify experimental methods, and tables that outline and compare experimental
choices. The last part of each chapter provides practical applications and
examples that relate the topic to the actual design and implementation of
a neuroprosthetic system or device.
Through its exploration of a variety of developmental processes, the book
provides guidance on issues that have yet to be solved, strategies for solving
such problems, and the pitfalls often encountered when developing neural
prostheses. Whether you are new to or a veteran of the field, whether you
work directly or indirectly with neuroprosthesis projects, the Handbook of
Neuroprosthetic Methods provides an accessible common ground for all involved
in neuroprosthetic design and research.
Influence of Stress on Cell Growth and Product Formation
Springer-Verlag; 2000; pp190; ISBN: 3-540-66687-7
Advances in Biochemical Engineering Biotechnology, vol.67
Stresses which arise in bioreactors can influence process performance considerably.
Recent molecular biological investigations indicate that stress caused by
fluid dynamical effects and extreme values of process variables and toxic
substances cause similar responses in the cells. These molecular fundamentals,
as well as quantitative evaluation of fluid dynamical stresses and, their
effects on microorganisms, animal and plant cells and proteins are treated
in this volume.
Methods in Genomic Neuroscience
Hemin R Chin, Steven O Moldin
CRC Press; 2001; pp344; ISBN: 0849323975
Methods and New Frontiers in Neuroscience, Volume: 10
Discusses state-of-the-art methods used to characterize the genetic basis
of the nervous system and complex behavior
Presents clearly written chapters, making each methodology accessible
to neuroscientists with different levels of experience and expertise in molecular
techniques
Provides researchers with detailed information for choosing and implementing
the appropriate genetic methodology for their application
The past few years have witnessed extraordinary advances in molecular genetic
techniques and the accumulation of structural genomics information and resources
in both human and model organisms. With the development of new technologies
and the availability of resources like the sequence of eukaryotic genomes,
problems of a previously unthinkable scope are now being routinely solved
in neuroscience and many other areas of biomedical research. The results
of these studies, in turn, are having, and will continue to have, profound
impact on experimental approaches and designs for manipulating genes, the
genome, and model organisms as a means of gaining insights into nervous system
functioning and complex behavior.
Methods of Behavior Analysis in Neuroscience
Jerry J Buccafusco
CRC Press; 2000; pp352; ISBN: 084930704X
Methods and New Frontiers in Neuroscience Vol.3
Presents step-by-step, easy-to-reproduce methodology
Requires no prior training in animal behavior or general behavioral science
Represents the general consensus as determined from the most recent scientific
literature
Using the most well-studied behavioral analyses of animal subjects to promote
a better understanding of the effects of disease and the effects of new
therapeutic treatments on human cognition, Methods of Behavior Analysis
in Neuroscience provides a reference manual for molecular and cellular research
scientists in both academia and the pharmaceutical industry. The materials
presented draw from the scholarly works of recognized experts in several
fields of cognitive and behavioral neuroscience.
Each contributor describes the most frequently used and most widely accepted
version of the model, and each chapter includes: (1) a well-referenced introduction
that covers the theory behind and the utility of the model; (2) a detailed
and step-by-step methodology; and (3) an approach to the interpretation
of the data presented. Many chapters also provide examples of actual experiments
that use the method.
This text eliminates the guesswork from the process of designing the methodology
for many of the animal behavioral models that are used to study brain disorders,
drug abuse, toxicology, and cognitive drug development. It will also significantly
reduce the time spent assessing literature and developing models for studying
animal subjects. Overall, Methods of Behavioral Analysis in Neuroscience
is an invaluable reference source for the professional who seeks to comprehend
the effects of disease on human cognition.
Molecular Neuroscience
Patricia Revest, A. Longstaff
Coronet Books; 1997; pp240; ISBN: 1859962505
Molecular Neuroscience is written to give students insight into how neuroscience
has been revolutionized at the molecular level during the past decade. It
serves as a broad introduction to many of the ingenious approaches molecular
biologists have used to fathon neural function, and outlines key findings
in relation to aspects of neuroscience currently at the cutting edge. The
book provides sufficient familiarity with molecular biology techniques such
as applied to neuroscience discover that the exciting (and voluminous) literature
in this area becomes accessible.
Molecular Neuroscience is written for 2nd and 3rd year life science undergraduats,
medical student, researchers, and technicians requiring a concise introduction
to the field.
Neural Stem Cells: Methods and Protocols
Ed. T. Zigova, P. R. Sanberg, and J. R. Sanchez-Ramos
Humana Press; 2002; pp400; ISBN: 0896039641
Methods in Molecular Biology, vol.198
In Neural Stem Cells: Methods and Protocols, internationally recognized
experts from academic, clinical, and pharmaceutical laboratories describe
in great detail the most frequently used cellular, molecular, and electrophysiological
methods to isolate, characterize, and utilize neural stem cells. These readily
reproducible techniques introduce the various sources of stem/progenitor
cells, provide a wide range of conditions for their culture, and make it
possible to define their properties in culture. Additional techniques are
designed to help researchers identify endogenous stem cells as well as exogenous
stem cells after transplantation in the brain. The protocols range from the
simplest methods of isolation and characterization of neural cell properties
to such very sophisticated methods as characterizing gene expression, telomerase
assays, and cell cycle kinetics.
Neuroanatomy: An Atlas of Structures, Sections, and Systems, 6th Edition
Duane E. Haines
Lippincott, Williams & Wilkins; 2003; pp303; ISBN: 0-7817-4677-9
Previous editions of this best-selling atlas gave students a structural
basis for understanding the function of the central nervous system by integrating
neuroanatomical and clinical information. This new Sixth edition continues
the clinically oriented approach, presenting structural information and
concepts in an even more clinically relevant format. The goal is to ensure
that the transfer of basic science information to the clinical environment
is easy, immediate, and seamless.
Many changes and improvements have been made to meet this goal. First,
over 110 new images and illustrations were added (including MRI, CT, color
line drawings, and brain specimens) to emphasize anatomical-clinical correlations.
Secondly, anatomical information on the brainstem and spinal cord is now
shown in the same orientation in which it is viewed in the diagnostic setting.
Presenting the anatomical information in this format allows the information
to be immediately accessible, and applicable, to the requirements of the
clinical environment. Lastly, Figure descriptions have been improved. In
some instances, existing figures have been relocated to improve their correlation
with other images. In other instances existing figures have been repeated
and correlated with newly-added MRI and CT so as to more clearly illustrate
an anatomical-clinical correlation. With these improvements, this atlas has
an even stronger clinical emphasis than ever before.
Other Features and Highlights Include:
o Chapter 5 now presents images in a format that allows the user to view
internal spinal cord and brainstem anatomy in either anatomical or clinical
orientations. These orientation options appear as a series of thumbnail
images on all spinal cord and brainstem pages of Chapter 5.
o New MRIs and CTs are introduced into Chapter 2 (The Spinal Cord, Cranial
Nerves, Meningeal Hemorrhages, Hemorrhage Into the Brain and Ventricles).
These new diagnostic images correlate with anatomical images located on
the same page, on the facing page, or on an immediately adjacent page.
o New Images in Chapter 8 show the blood supply to the choroids plexus
of the lateral, third, and fourth ventricles and the vasculature of the
brain in MRA.
o Review Questions: A totally new chapter has been added, featuring more
than 235 questions, most in the USMLE-style, with rationales.
Give your students the one neuroanatomy atlas that bridges the gap between
the classroom and the clinic.
Neurobiology of Aggression, Understanding and Preventing Violence
Mattson, Mark P
Humana Press; 2003; pp336; ISBN: 158829188X
Contemporary Neuroscience
This interdisciplinary review of the cellular and molecular basis of aggression
shows how the nerve cell circuitry and the neurochemistry that mediates
aggressive behaviors are modified by various environmental and genetic factors.
The authors focus on the links to cognition and the neurotransmitter pathways
that either promote or suppress violent behavior. They also examine how family
environment, early life experiences, exposure to violent video games and
movies, religion, and substance abuse effect violent behaviors, including
participation in gangs and terrorist organizations. Various behavioral and
pharmacological approaches are presented for preventing and treating personal
aggression.
Neurodegeneration Methods and Protocols
Ed. Harry, Jean ; Tilson, Hugh A.
Humana Press; 1998; pp328; ISBN: 089603612X
Methods in Molecular Medicine, vol.22
An outstanding collection of detailed, state-of-the-art techniques for
studying many aspects of nervous system cell biology. The methods span a
multidisciplinary range of cellular and molecular approaches to both normal
and injured nervous system function, and particularly to neurodegenerative
processes. Included are basic RT-PCR techniques, cell culture systems, second-messenger
signaling methods, and patch-clamp techniques. These powerful techniques
will illuminate nervous system function, injury, degeneration, and the repair/regenerative
process.
Neurogenetics, Methods and Protocols
Ed. Potter, Nicholas T.
Humana Press; 2002; pp408; ISBN: 0896039900
Methods in Molecular Biology, vol.217
An international panel of recognized academic physicians, researchers,
and clinical laboratory diagnosticians describe their best methods for characterizing
neurologically relevant genes, their mutations, and their proteins. Providing
detailed step-by-step instructions to assure successful experimental results,
these experts cover the key methods for mutation detection and screening,
including discussions of quantitative PCR, trinucleotide repeat detection,
sequence-based mutation detection, fluorescence in situ hybridization (FISH),
in vitro protein expression systems, and studies of protein expression and
function.
Neuroinflammation Mechanisms and Management, 2nd ed.
Wood, Paul L.
Humana Press; 2002; pp436; ISBN: 1588290026
Contemporary Neuroscience
In this thoroughly updated and revised edition of his much praised book,
Paul L. Wood and a panel of leading researchers capture these new developments
in a masterful synthesis of what is known today about the inflammatory mediators
and cells involved in neurodegenerative diseases. This second edition contains
extensive updates on the mediators produced by microglia and their role
in neuroinflammatory-induced neuronal lysis. There is also increased coverage
of the animal models used in the study of neuroinflammatory mechanisms,
of the new imaging methods that allow the noninvasive evaluation of microglial
activation in human neurodegernerative disorders, and of the role of neuroinflammation
in amyloid-dependent neuronal lysis.
Neurological Foundations of Cognitive Neuroscience
Mark D'Esposito
MIT Press; 2002; pp301; ISBN: 0262042096
Despite dramatic advances in neuroimaging techniques, patient-based analyses
of brain disorders continue to offer important insights into the functioning
of the normal brain. Bridging the gap between the work of neurologists studying
clinical disorders and neuroscientists studying the neural mechanisms underlying
normal cognition, this book reviews classical neurobehavioral syndromes
from both neurological and cognitive scientific perspectives.
The contributors are all practicing neurologists who also conduct cognitive
neuroscience research. Each chapter begins with a case study, describing
the patient’s symptoms and the cognitive processes involved. The clinical
descriptions are followed by historical background on the neurobehavioral
syndromes and discussion of the methods used to understand the underlying
neural mechanisms. In their attempts to reconcile conflicting data derived
from different methodologies, many of the authors shed new light on the cognitive
mechanisms they discuss. The syndromes include neglect, Balint’s syndrome,
amnesia, semantic dementia, topographical disorientation, acquired dyslexia,
acalculia, transcortical motor aphasia, Wernicke’s aphasia, apraxia, and
lateral prefrontal syndrome.
Neuropeptide Protocols
Ed. Irvine, G. Brent; Williams, Carvell H.
Humana Press; 1996; pp400; ISBN: 0896033996
Methods in Molecular Biology, vol.73
Leading scientists offer an unprecedented suite of master protocols for
analyzing neuropeptide structure and function using optimized classic methods
and the latest state-of-the-art techniques. This comprehensive collection
includes valuable techniques for extracting and purifying neuropeptides from
biological sources, for their sequence determination by Edman degradation
and PCR, and for the solid-phase synthesis and purification of peptides and
peptide analogs. Also covered are physical techniques for the characterization
of synthetic or natural peptides, methods for immunocytochemical sample preparation
and visualization at both light and electron levels, and techniques for neuropeptide-receptor
interaction. Chapters on molecular modeling, radioisotopic labeling, production
of antisera, the measurement of efflux from brain to blood, and the assay
and inhibition of neuropeptidases complete this indispensable collection
of readily reproducible protocols.
Neuropeptide Y Protocols
Ed. Balasubramaniam, Ambikaipakan
Humana Press; 2000; pp256; ISBN: 0896036626
Methods in Molecular Biology, vol.153
A strong cohort of established investigators from a variety of disciplines
detail their best techniques for advancing NPY research. Among the many
readily reproducible methods described are those for cloning, for the production
of transgenic and knockout models, and for the use of antisense technology
to define the receptors and the signal transduction pathways mediating NPY
actions. A range of the major qualitative and quantitative techniques used
to study tissue mRNA distribution are also included, as well as methods for
radioligand binding. Highly practical and state-of-the-art, Neuropeptide
Y Protocols constitutes a gold-standard collection of proven techniques for
advancing today's understanding of this significant neuropeptide, as well
as for developing the promising NPY-based therapeutics now emerging for many
important disorders.
Neuropharmacology Methods in Epilepsy Research
Steven L Peterson, Timothy E Albertson
CRC Press; 1998; pp304; ISBN: 0849333628
Methods in Life Science - Cellular & Molecular Neuropharmacology Vol.
2
Examines in vivo animal model approaches
Analyzes critical issues affecting seizure responses, i.e. circadian
effects, genetics, cognitive effects
Discusses underlying biological changes
Provides a spectrum of screening platforms for potential antiepileptic
drugs
Enables readers to develop experimental techniques by detailing procedures
There is an estimated 2.5 million epileptics in the US and perhaps some
40 million worldwide. As research has become increasingly molecular in scope,
fewer scientists are trained in the US on basic, integrated epilepsy techniques.
One frustration in neuroscience today is the application of state-of-the-art
molecular biology techniques to inappropriate animal models of epilepsy
- frequently resulting in inconclusive results. Epilepsy research will be
increasingly undertaken by scientists well-trained in reductionist methodology,
but who may be unfamiliar with integrated, whole-animal techniques. This
situation appears even more difficult considering there has been no updated
textbook on experimental models of epilepsy over the last twenty years -
until now.
Neuropharmacology Methods in Epilepsy Research describes fundamental methodologies
and procedures in this field, representing the only detailed text concerning
experimental models of epilepsy published in the last 20 years. This guide
studies the reproduction of well-characterized and readily interpretable
experimental models of epilepsy to which state-of-the-art molecular biology
techniques can be applied.
Neurotransmitter Methods
Ed. Rayne, Richard C.
Humana Press; 1997; pp288; ISBN: 0896033945
Methods in Molecular Biology, vol.72
This outstanding and comprehensive collection of user-friendly protocols
is essential for neuroscientists who wish to localize, identify, purify,
and/or quantify neurotransmitters. The easily reproducible methods presented
cover a broad spectrum of approaches involving cell and organ culture, histochemistry,
immunochemistry, in situ hybridization, cell fractionation, liquid chromatography,
mass spectrometry, in vivo microdialysis, and voltammetry. These approaches
are optimized for use by neuroscientists, are often complementary, and can
be employed in tandem with powerful effect.
Neurotransmitters and Neuromodulators: Handbook of Receptors and Biological
Effects
Oliver von Bohlen und Halbach, Rolf Dermietzel
John Wiley & Sons; 2002; pp291; ISBN: 3527303189
What are the biological effects of neuropeptides and other neuroactive
substances? What are their receptors, their pharmaceutical applications?
The intensive search for answers to these questions culminated in the 2000
Nobel Prize for Medicine/Physiology being awarded to A. Carlsson, P. Greengard,
and E. Kandel for their pioneering research in signal transduction in the
nervous system.
This handbook gives a short but detailed overview of neuroactive substances,
covering all neurotransmitters and most neuromodulators. It provides clear
and comprehensive information on their biosynthesis and degradation, localization,
receptors, signal transduction pathways, and biological effects in the central
nervous system. Introductory chapters on general aspects and on methods
for analyzing neuroactive substances make this a valuable tool for researchers,
teachers, and advanced students in molecular biology, biochemistry, medicine,
neurosciences, pharmacology, and physiology.
Neurotransmitters, Drugs and Brain Function
Ed. Roy Webster
John Wiley & Sons; 2001; pp544; ISBN: 0471978191
This book aims to cover the role of neurotransmitters, the substances released
form neurons to act on neurons. It covers what they do, how they do it and
how their activity is involved in brain function and affected by drugs and
disease.
The contents include:
An overview of neurotransmitter function including their release, effects
on neuronal excitability and receptor interaction
Detailed description of the synaptic physiology, pharmacology and possible
brain function of each neurotransmitter with particular emphasis on acetylcholine,
glutamate, GABA, noradrenaline, dopamine, 5 hydroxytryptamine and the peptides,
purines, histamine, steroids and nitric oxide
An evaluation on how the different neurotransmitters may be involved
in the initiation and maintenance of certain brain disorders such as Parkinson's
disease, epilepsy, schizophrenia, depression, anxiety and dementia
A review of neurotransmitters in sleep and consciousness and in the social
problems of drugs and abuse
Neurotransmitters, Drugs and Brain Function provides insights that will
prove invaluable to students and researchers involved in pharmacology, neuroscience,
medicine and psychology.
Neurotrophin Protocols
Ed. Rush, Robert A.
Humana Press; 2000; pp288; ISBN: 0896036995
Methods in Molecular Biology, vol.169
In Neurotrophin Protocols, established leaders in the neurotrophin field
detail their special expertise in a wide variety of key protein, RNA, recombinant,
and in vivo techniques. The protocols range from immunological analysis
for the cellular localization and quantification of the neurotrophins, to
genetic manipulation of cells and animals for analysis of biological function,
to quantitative analysis of the active neurotrophin genes. There are also
radiotracing techniques for studying neurotrophin transport in both the
retrograde and anterograde directions, procedures for using immunotoxins
to study the effects of eliminating a single class of neurons, and the essential
stereological method for estimation of neuronal numbers. Timely and robust,
Neurotrophin Protocols provides today's neuroscientists in both academia
and industry with a comprehensive range of practical, readily reproducible
methods for studying neurotrophins and the critically important effects they
have on the nervous system.
New Concepts in Cerebral Ischemia
Rick C. S. Lin
CRC Press; 2001; pp328; ISBN: 084930119X
Methods and New Frontiers in Neuroscience Vol. 13
o Includes a wide range of new concepts, modern technology, and new models
for investigating the basis for neuronal injury
o Presents new methods and therapeutic approaches for neuronal protection
against acute and chronic ischemic episodes
o Addresses both basic and clinical issues regarding the future of ischemia
research
o Describes new animal models for ischemia research including the application
of transgenic animals and stem cells transplantation
Approximately half a million Americans suffer brain ischemic episodes every
year. These brain strokes are the third leading cause of death in the United
States and the number-one cause of permanent disability. Over the past decade,
we have made extensive attempts to understand the biological mechanisms
that underlie stroke-induced neuronal injury. This research has been benefited
by the introduction of a variety of new technologies and assays aimed at
deciphering the complex neuronal degenerating processes triggered by cerebral
vascular disorders or other neurological diseases that produce ischemic episodes.
New Concepts in Cerebral Ischemia presents techniques and theories for
understanding the various stages of early pathogenesis in order to design
specific strategies to protect neurons from further injury. Short, specific,
and comprehensive chapters provide detailed descriptions of the new methods
employed in both basic and clinical research that are revolutionizing the
field of ischemia research. Written by international experts in CNS dysfunction,
the book includes methods to elucidate the pathogenesis of ischemia, technologies
used in the design of specific strategies to protect neurons from further
injury, and new approaches to treat patients with acute ischemic episodes.
With this book, you will gain new insights not only into cerebral vascular
research, but also into neurological disease in general.
Nicotinic Receptors in the Nervous System
Edward D Levin
CRC Press; 2001; pp312; ISBN: 084932386X
Methods and New Frontiers in Neuroscience Vol. 8
Uses an approach that integrates molecular and neurochemical behavioral
applications in translational animal behavior models and clinical applications
Presents the work of distinguished researchers in the field
Includes the latest reviews of nicotine research on the molecular, neurochemical,
translational, and clinical levels of analysis
Discusses the function of neural nicotinic systems and the significance
for diseases such as schizophrenia, Alzheimer's disease, Tourette's syndrome,
and ADHD
Nicotine research has been conducted for the better part of a century,
but with the discovery of the relationship of nicotinic systems to Alzheimer's
disease, the differentiation of nicotinic receptor subtypes, and the development
of novel nicotinic ligands, the field of nicotine research has exploded.
This book will provide you reference to the latest research methods and findings
concerning nicotinic neural systems.
Featuring a unique approach, Nicotinic Receptors in the Nervous System
provides integrated coverage of cutting-edge research concerning neuronal
nicotinic systems relevant to smoking addiction and cognitive dysfunction.
By bringing together molecular and neurochemical applications, this book
provides the key to understanding function and dysfunction of nicotinic
systems and how they are significant for disease, addiction, and the development
of novel drug treatments.
Within the next several years, it is very promising that clinical research
will support the use of nicotinic treatments for addiction, pain, and cognitive
and motor dysfunction. Nicotinic Receptors in the Nervous System provides
you with the basic mechanistic background for these treatments as well as
the functional assessment necessary to determine therapeutic effects.
NMDA Receptor Protocols
Ed. Li, Min
Humana Press; 1999; pp208; ISBN: 0896037134
Methods in Molecular Biology, vol.128
Min Li and a panel of hands-on experimentalists detail state-of-the-art
molecular techniques for studying NMDA ligand-gated ion channels and developing
assays for nontherapeutic lead selection. The topics range from cDNA cloning
to in vitro and in vivo investigation of the channel complex in the mammalian
brain. Additional topics include the biochemical analysis of the channel
protein and the construction of various heterologous systems for both basic
research and high throughput screens (HTS) for pharmaceutical chemicals.
Although the focus is on NMDA receptors, the methods are applicable to other
ligand-gated ion channels and with some modification may be extended to related
membrane signaling receptors. NMDA Receptor Protocols offers today's scientists
powerful methods for basic research on NMDA receptor structure and function,
as well as enormous opportunities for clinical investigation toward the development
of novel bioactive compounds.
Opioid Research: Methods and Protocols
Ed. Pan, Zhizhong Z.
Humana Press; 2003; pp308; ISBN: 1592593798
Methods in Molecular Medicine, vol.84
This comprehensive collection of the major cross-disciplinary methods and
protocols used in current opioid research covers topics ranging from molecular
and genetic techniques, to behavioral analyses of animal models and to clinical
practices. The well-practiced authors describe their best molecular techniques
for the cloning and expression of opioid receptors, and for the quantitative
characterization of their signaling pathways, as well as for mapping the
distribution and detecting the expression levels of opioid receptors, opioid
peptides, and their messages in both brain tissues and individual cells.
Also included are methods for the creation of in vitro and in vivo animal
models to study opioid functions, as well as the clinical applications in
the treatment of pain and opioid addiction.
p53 Protocols
Ed. Deb, Sumitra; Deb, Swati Palit
Humana Press; 2003; pp300; ISBN: 1588291065
Methods in Molecular Biology, vol.234
An indispensable collection of novel techniques that have proven most useful
for studying the physiological properties of p53 both in vitro and in vivo.
The techniques provide proven solutions to problems in studying the purification,
target identification, gene expression, quantitation, interaction, signaling,
transactivation, and transrepression of p53. The methods are also useful
for delineating the functions of other proteins that may act as tumor or
growth suppressors. Each technique includes step-by-step instructions, troubleshooting
notes, a theoretical review, and discussion of associated problems that
might arise during the course of investigation.
Parkinson's Disease Methods and Protocols
Ed. Mouradian, M. Maral
Humana Press; 2001; pp336; ISBN: 1592591426
Methods in Molecular Medicine, vol.62
Internationally recognized biomedical investigators describe in detail
the major techniques employed in molecular and cellular studies of Parkinson's
disease and basal ganglia function. Widely varied methods are covered, including
genetic analyses, molecular pathogenetic investigations of dopaminergic
neuronal degeneration, biochemical studies of nigro-striatal neural circuitry,
and molecular therapies, such as gene therapy and neural stem cells. Comprehensive
and timely, Parkinson's Disease: Methods and Protocols offers scientists
and clinicians interested in Parkinson's and related neurodegenerative disorders
the major cutting-edge methods-in a readily reproducible format-needed to
effectively exploit the potential of cell and molecular biology for elucidating
disease mechanisms and for speeding the emergence of novel and more effective
therapeutics.
Pathogenesis of Neurodegenerative Disorders
Mattson, Mark P.
Humana Press; 2001; pp304; ISBN: 0896038386
Contemporary Neuroscience
In this groundbreaking book, leading experts detail the cellular and molecular
cascades that cause selective degeneration of neuronal populations, and
illuminate those genetic and environmental factors that are critical to
the facilitation or suppression of the neuropathologic processes. Working
from studies of human patients, as well as from cell culture and animal models,
the authors demonstrate a heretofore unrecognized convergence of the causative
pathogenetic mechanisms for clinically distinct neurological disorders. At
center stage are the biochemical and molecular cascades that will ultimately
lead to neuronal death-cascades involving oxyradical production, aberrant
regulation of cellular ion homeostasis, activation of specific proteases,
and activation of a stereotyped sequence of events involving mitochondial
dysfunction. Individual chapters examine how these mechanisms-along with
genetic and environmental factors-operate in Alzheimer's and Parkinson's
diseases, Down's syndrome, amyotropic lateral sclerosis, ischemic stroke,
spinal cord injury, and Duchenne muscular dystrophy.
Phospholipid Signaling Protocols
Ed. Bird, Ian
Humana Press; 1998; pp400; ISBN: 0896034917
Methods in Molecular Biology, vol.105
This wide-ranging collection of state-of-the-art techniques for the assay
of phospholipid and phospholipid-derived second messengers allows the identification
and quantification of signal pathway activation. The assays described cover
all the major phospholipases (C, D, A2), as well as sphingomyelinase and
associated metabolites. Additional protocols are provided for the assay of
phosphoinositide 3-, 4-, and 5-kinase activity and for the separation and
identification of phospholipids, diacylglycerol and sphingolipids, as well
as their phosphoinositol, choline, and fatty acid metabolites. Detailed,
step-by-step instructions make this book suitable for both the newcomer and
the experienced investigator.
Protocol for Neural Cell Culture (3rd Edition)
Ed. S.Fedoroff, A.Richardson
Humana Press; 2001; pp384; ISBN: 0-89603-902-1
Sergey Fedoroff and Arleen Richardson extensively revise, update, and expand
their best-selling and highly praised collection of readily reproducible
neural tissue culture protocols. This 3rd edition adds 11 new chapters describing
important new procedures for the isolation, growth, and characterization
of neural stem cells and for the manipulation of glial progenitor cells,
as well as are essential procedures for hippocampal and microglial slice
cultures. Protocols for Neural Cell Culture: Third Edition is a richly augmented
updating of the tried and tested laboratory procedures that have made earlier
editions an indispensable reference and guide to neural cell culture and
its disorders.
Psychiatric Genetics: Methods and Reviews
Ed. Leboyer, Marion ; Bellivier, Frank
Humana Press; 2002; pp280; ISBN: 1592593488
Methods in Molecular Medicine, vol.77
Psychiatric Genetics provides the reader with a complete view of the methodological
problems encountered in psychiatry genetics and proposes solutions to commonly
occurring questions. The best European and American specialists have given
a thorough review on the advantages and disadvantages of genetic epidemiological
methods, the way to choose a genetic marker or a clinical interview and
how to ascertain patients, unaffected relatives and controls and what should
be the criteria to include a case or a control. New phenotypic methods are
described focusing on candidate symptom and endophenotype approaches. Examples
coming from cognitive neurosciences, biochemistry, electrophysiology and
brain imaging techniques are reviewed. This book will serve as an essential
handbook for psychiatrists, psychologists, and geneticists involved in the
genetics of psychiatric disorders.
Psychiatry as a Neuroscience
Ed. Juan Jose Lopez-Ibor, Wolfgang Gaebel, Mario Maj, Norman Sartorius
John Wiley & Sons; 2002; pp346; ISBN: 0471496561
Psychiatry as a Neuroscience provides an overview of recent solid advances
in biological psychiatry which are of clinical relevance. These include
psychoneuroendocrinological and psychoimmunological findings in major
depression
genetic and neuroimaging data in schizophrenia
molecular genetic findings in Alzheimer's disease
neuroimaging data in obsessive-compulsive disorder.
This book will be of interest to psychiatrists and psychologists, neuroscientists,
managers and policy makers.
Psychiatry in Society
Ed. Norman Sartorius, Wolfgang Gaebel, Juan Jose Lopez-Ibor, Mario Maj
John Wiley & Sons; 2002; pp304; ISBN: 0471496820
Psychiatry in Society provides an overview of the recent socio-economic
and cultural changes affecting mental health and mental health care.
These changes include:
The increasing complexity of the economic contexts within which mental
health services are funded and delivered
The demand for cost-effectiveness evidence
The rationing of access to new pharmacotherapies and psychotherapies
The emergence of quality of life as an essential criterion in the assessment
of health care interventions
The growing awareness of the influence of stigma on shaping the long-term
course of severe mental disorders
The enhanced role of advocacy groups in providing information, advice
and support to sufferers.
This book will be of interest to psychiatrists and psychologists, mental
health workers, managers and policy makers.
Receptor Signal Transduction Protocols
Ed. Challiss, R. A. J.
Humana Press; 1997; pp296; ISBN: 0896034186
Methods in Molecular Biology, vol.83
An outstanding collection of state-of-the-art methods from leading experts
for interrogating ligand-receptor and receptor-effector interactions. The
methods emphasize the regulation of G protein-coupled receptors and focus
on receptor characterization, methods for investigating how receptors couple
to G proteins, and approaches to studying how receptor expression and function
is regulated. The easily reproducible protocols include chimeric receptor
construction, antibody generation, transient and stable transfection methods,
in situ hybridization, as well as immunocytochemistry, functional assays
of G protein function, antisense methods for defining receptor-effector coupling
pathways, and many more.
Receptor Signal Transduction Protocols, 2nd ed
Ed. Willars, Gary B.; Challiss, R. A. John
Humana Press; 2004; pp465; ISBN: 1588293297
Methods in Molecular Biology, vol.259
This new edition combines updates of key chapters from the first edition
with a large number of new key methodologies that have emerged more recently
for studying G protein-coupled receptors (GPCRs) and events immediately
downstream of their activation. The methods are focused primarily on events
at the receptor level, including ligand binding, the genetic manipulation
of receptors, the generation of model cell lines in which to study them,
and the interaction and activation of G-proteins. Additional methods concentrate
on receptor expression and localization, receptor internalization and post-translational
modification, GPCR–protein interactions, and the use of knock-out and knock-in
strategies for determining the physiological roles of receptors.
Signal Transduction
Bastien Gomperts, Ijsbrand Kramer, Peter Tatham
Academic Press (now a part of Elsevier Science); 2002; pp420; ISBN: 0-12-289631-9
Signal Transduction is a well-illustrated, coherent look at cellular signaling
processes. Beginning with the basics, it explains how cells respond to external
cues, hormones, growth factors, cytokines, cell surfaces, etc., and then
shows how these inputs are integrated and coordinated. The extensive color
artwork provides the reader with a clearer comprehension of key topics, and
margin notes are incorporated to highlight milestones in the evolution of
signal transduction. This book serves as an invaluable resource for advanced
undergraduates, graduate researchers, and established scientists working
in cell biology, pharmacology, immunology, and related fields.
Signal Transduction and Human Disease
Ed. Toren Finkel, J. Silvio Gutkind
John Wiley & Sons; 2003; pp488; ISBN: 0471020117
The past few years have witnessed rapid progress in the characterization
of mechanisms that underlie the generation and processing of inter- and
intracellular signals. While there have been significant corollary advances
in the area of signaling in disease processes, there is as yet no single
resource that connects these advances with an understanding of disease processes
and applications for novel therapeutics. Collecting chapters from the leading
experts in their respective fields, editors Toren Finkel and Silvio Gutkind
deliver a much-needed introduction to signaling and a fruitful discussion
of promising directions for future research.
Signal Transduction and Human Disease capitalizes on the current emphasis
on translational research and biological relevance in biotechnology and,
conversely, the importance of molecular approaches for clinical research.
Each chapter conveys the sense of a disease process, what it affects, how
it presents, how common it is, and what the treatments are. Clinical descriptions
are not exhaustive but rather serve as an outline regarding the disease’s
manifestations and current treatment options. Following this introduction,
the authors present an in-depth discussion of one or two signal transduction
pathways or biological processes relevant to the disease. The editors divide
their study into five sections:
Cardio-Pulmonary Disease
Oncology
Endocrinology
Infectious Disease
Allergy/Rheumatology
Neurology/Psychiatry
Biochemists, molecular and cell biologists, immunologists, pharmacologists,
and clinical researchers, as well as graduate students in a variety of scientific
disciplines, will find Signal Transduction and Human Disease to be an invaluable
addition to the literature.
Signal Transduction Protocols
Ed. Kendall, David A.; Hill, Stephen J.
Humana Press; 1995; pp316; ISBN: 0896032981
Methods in Molecular Biology, vol.41
This collection of self-contained, “hands-on” descriptions of established
laboratory protocols concentrates on receptor-mediated cell signaling, with
particular attention devoted to those receptors that are part of the G-protein-linked
superfamily. It offers those already working in the field as well as those
in related areas the opportunity to expand their range of experimental techniques
and to carry out successful investigations without needing to refer to any
other methodological source.
Signaling Molecules: Roles in Differentiation and Proliferation
pp42
Signaling Networks and Cell Cycle Control. The Molecular Basis of Cancer
and Other Diseases
Ed. IJ.S.Gutkind
Humana Press; 2000; pp592; ISBN: 0-89603-710-X
Cancer Drug Discovery and Development, vol 5
Leading scientists summarize the latest findings on signal transduction
and cell cycle regulation and describe the effort to design and synthesize
inhibiting molecules, as well as to evaluate their biochemical and biological
activities. They review the relevant cell surface receptors, their ligands,
and their downstream pathways. Also examined are the latest findings on the
components of novel signaling networks controlling the activity of nuclear
transcription factors and cell cycle regulatory molecules. Cutting-edge and
highly suggestive, Signaling Networks and Cell Cycle Control: The Molecular
Basis of Cancer and Other Diseases presents a wealth of information on the
emerging principles of the field, as well as an invaluable guide for all experimental
and clinical investigators of cell regulation and its rapidly emerging pharmacological
opportunities today.
Stem Cell Biology
Ed. D.R.Marshak, R.L.Gardner, D.Gottib
Cold Spring Harbour Laboratory Press ; 2001; pp550; ISBN: 0-87969-673-7
Stem cells are the focus of intense interest from a growing, multidisciplinary
community of investigators with new tools for isolating and characterizing
these elusive cell types. This volume, which features contributions from
many of the world's leading laboratories, provides a uniquely broad and authoritative
basis for understanding the biology of stem cells and the current excitement
about their potential for clinical exploitation. It is an essential work
of reference for investigators in embryology, hematology, and neurobiology,
and their collaborators in the emerging field of regenerative medicine.
Stem Cell Biology and Gene Therapy
Ed. P.J.Quesenbberry, G.S.Stein, B.G. Forget, S.M.Weisman
John Wiley & Sons; 1998; pp584; ISBN: 0-471-14656-0
This self-contained volume integrates biological and clinical components
of stem cell biology, examines some of the most difficult aspects of gene
therapy, and provides a systematic review of advanced gene modification
techniques. Twenty essays by leading researchers address some of the most
compelling topics in contemporary medical research, including:
< cells stem in operate that mechanisms regulatory>
Stem cells from a therapeutic perspective, including preparations of
stem cells and their therapeutic potential as vehicles for gene therapy
Delivery systems for therapeutic genes, including an overview of the
most promising vectors
Clinical applications for gene therapy, covering a broad range of diseases
such as hemophilia, cancers, neurological disease, and more
Complete with illustrations and real-world examples of a variety of disorders,
Stem Cell Biology and Gene Therapy is essential for researchers in gene
therapy and members of the biotechnology industry who are developing human
molecular therapies for commercial use. It is also an important reference
for molecular biologists, cell biologists, immunologists, molecular geneticists,
hematologists, cancer researchers, biochemists, and anyone working in internal
medicine.
Stem Cells
Ed. C.Potten
Academic Press (now a part of Elsevier Science); 1996; pp496; ISBN: 0125634552
Stem cells are relatively undifferentiated cells which are the permanent
lineage ancestor cells of tissues. Newly developed molecular biological
techniques and probes have made possible dramatic advances in our ability
to study the lineage development of stem cells. A major impetus to develop
these techniques has been to identify specific stem cells for gene therapy
purposes. The role that stem cells play in the development of cancer is
also an important area. This book provides up-to-date reviews on a wide
variety of stem cell systems by world experts. Chapters range from descriptions
of the current knowledge of the biology of stem cells, to current molecular
biological approaches and clinical implications. Oncologists and cell biologists
will find this book of particular interest. It will also be usefule to radiobiologist,
biotechnologists, and gene therapists.
Stem Cells and the Future of Regenerative Medicine
Committee on the Biological and Biomedical Applications of Stem Cell Research
National Academies Press; 2002; pp112; ISBN: 0-309-07630-7
Recent scientific breakthroughs, celebrity patient advocates, and conflicting
religious beliefs have come together to bring the state of stem cell research—specifically
embryonic stem cell research—into the political crosshairs. President Bush’s
watershed policy statement allows federal funding for embryonic stem cell
research but only on a limited number of stem cell lines. Millions of Americans
could be affected by the continuing political debate among policymakers
and the public.
Stem Cells and the Future of Regenerative Medicine provides a deeper exploration
of the biological, ethical, and funding questions prompted by the therapeutic
potential of undifferentiated human cells. In terms accessible to lay readers,
the book summarizes what we know about adult and embryonic stem cells and
discusses how to go about the transition from mouse studies to research
that has therapeutic implications for people.
Perhaps most important, Stem Cells and the Future of Regenerative Medicine
also provides an overview of the moral and ethical problems that arise from
the use of embryonic stem cells. This timely book compares the impact of
public and private research funding and discusses approaches to appropriate
research oversight.
Based on the insights of leading scientists, ethicists, and other authorities,
the book offers authoritative recommendations regarding the use of existing
stem cell lines versus new lines in research, the important role of the
federal government in this field of research, and other fundamental issues.
Stem Cells: Scientific Progress and Future Research Directions
Dir. Ruth Kirschstein, M.D., Lana R. Skirboll
National Institutes of Health (NIH); 2001; pp222
The makings of future news headlines about tomorrow's life saving therapies
starts in the biomedical research laboratory. Ideas abound; early sucesses
and later failures and knowledge gained from both; the rare lightning bolt
of an unexpected breakthrough discovery — this is a glimpse of the behind
the scenes action of some of the world's most acclaimed stem cell scientists'
quest to solve some of the human body's most challenging mysteries.
Stem cells — what lies ahead? The following chapters explore some of the
cutting edge research featuring stem cells. Disease and disorders with no
therapies or at best, partially effective ones, are the lure of the pursuit
of stem cell research. Described here are examples of significant progress
that is a prologue to an era of medical discovery of cell-based therapies
that will one day restore function to those whose lives are now challenged
every day — but perhaps in the future, no longer.
Stress Response, Methods and Protocols
Ed. Keyse, Stephen M.
Humana Press; 2000; pp505; ISBN: 0896036111
Methods in Molecular Biology, vol.99
Chapters 21-28 are absent
It is now understood that the response of mammalian cells to a wide variety
of potentially toxic agents may be intimately linked with many human diseases,
including rheumatoid arthritis, ischemia, fever, infection, and cancer.
In Stress Response: Methods and Protocols, Stephen Keyse has assembled a
diverse collection of readily reproducible methods devoted to the study
of these varied and powerful responses. Written by leading researchers expert
in the techniques they describe, these detailed methods cover the detection
and assay of stress-induced damage, the activation of a wide range of signal
transduction pathways by cellular stress, stress-induced gene expression,
and stress protein function. To ensure experimental success, step-by-step
guidance is provided for each method, along with details of reagents, equipment,
and other requirements. The methods include both well-established techniques
and new technologies at the leading edge of research. Wide ranging and highly
practical, Stress Response: Methods and Protocols provides a gold-standard
bench manual for today's basic and clinical scientists working to understand
how cells and tissues respond during physiological stress and in human disease.
Suicide Gene Therapy: Methods and Reviews
Ed. Springer, Caroline J.
Humana Press; 2003; pp560; ISBN: 1592594298
Methods in Molecular Medicine, vol.90
The first comprehensive review of both the theory and practice of suicide
gene therapy. The authors cover all the major aspects of suicide gene therapy,
including the design and use of vectors in gene transduction, various enzyme
and prodrug systems, the mechanistic analysis of the bystander effect, the
design and synthesis of prodrugs, immunological implications, and its clinical
impact. They also describe all the cutting-edge methods needed to explore,
study, and advance understanding of the basic biology underlying gene therapy.
Each fully tested method includes step-by-step instructions, a discussion
of the principle behind the technique, equipment and reagent lists, tips
on troubleshooting and avoiding pitfalls, and notes on the interpretation
and use of results.
The Laboratory Mouse
Mark A Suckow , Peggy Danneman, Cory Brayton
CRC Press; 2000; pp184; ISBN: 0849303222
Provides instructions for the humane care of laboratory mice
Includes numerous figures that clearly illustrate concepts
Offers resources of relevance to laboratory mice and extensive references
for further study
Mice have been domesticated by humans for centuries, even millennia, and
have been used in research since the 1600's. However, development of the
laboratory mouse as a research model accelerated with genetic experiments
in the early 1900's. Today, the laboratory mouse is recognized as the pre-eminent
model for modern genetic research. In fact, over the last decade or so, most
biomedical research facilities have experienced increases of up to three
hundred percent in their mouse populations. Numerous other disciplines, including
immunology, cancer biology, toxicology, developmental biology, aging research,
and cardiovascular biology have recognized the mouse as a valuable research
model.
The Laboratory Mouse provides a single source reference for investigators,
technicians, and animal caretakers charged with the care and/or use of mice
in biomedical research. The book is particularly valuable to researchers
at small institutions and to those who work at facilities that lack large,
well-organized animal resource units.
The Laboratory Rat
Patrick Sharp, Marie LaRegina
CRC Press; 1998; pp240; ISBN: 084932565X
Laboratory Animal Pocket References, Volume: 4
Assists in the humane care and use of rats in the laboratory
Provides quick, easy-to-use information for investigators, technicians,
and animal caretakers
Includes references to alternative procedures and methods
Illustrates concepts and procedures with 31 figures
Summarizes data with 30 tables
Offers possible sources and suppliers of animals, feed, sanitation supplies,
cages, and research and veterinary supplies
Lists electronic resources, including web sites, for on-line research
Laboratory animals, including rats, play an important role in biomedical
research and advances. The humane care and management of these animals is
an ongoing concern. This guide was created especially for individuals performing
research with laboratory rats whose duties include animal facility management,
animal husbandry, regulatory compliance, and technical procedures involved
with their research. Basic information and common procedures are presented
in detail.
The MIT Encyclopedia of the Cognitive Sciences
Ed. R.A. Wilson, F.C. Keil
A Bradford book; 1999; pp964; ISBN: 0-262-73124-X
Since the 1970s the cognitive sciences have offered multidisciplinary ways
of understanding the mind and cognition. The MIT Encyclopedia of the Cognitive
Sciences (MITECS) is a landmark, comprehensive reference work that represents
the methodological and theoretical diversity of this changing field.
At the core of the encyclopedia are 471 concise entries, from Acquisition
and Adaptationism to Wundt and X-bar Theory. Each article, written by a
leading researcher in the field, provides an accessible introduction to
an important concept in the cognitive sciences, as well as references or
further readings. Six extended essays, which collectively serve as a roadmap
to the articles, provide overviews of each of six major areas of cognitive
science: Philosophy; Psychology; Neurosciences; Computational Intelligence;
Linguistics and Language; and Culture, Cognition, and Evolution. For both
students and researchers, MITECS will be an indispensable guide to the current
state of the cognitive sciences.
The Neuronal Environment, Brain Homeostasis in Health and Disease
Humana Press; 2001; pp428; ISBN: 0896038823
Leading neuroscience researchers offer a fresh perspective on neuronal
function by examining all its many components-including their pertubation
during major disease states-and relate each element to neuronal demands.
Topics range from the dependency of neurons on metabolic supply, as well
as on both ion and transmitter homeostasis, to their close interaction with
the myelin sheath. Also addressed are the astrocytic signaling system that
controls synaptic transmission, the extracellular matrix and space as communication
systems, the role of blood flow regulation in neuronal demand and in blood–brain
barrier function, and inflammation and the neuroimmune system. Insightful
and integrative, The Neuronal Environment: Brain Homeostasis in Health and
Disease demonstrates a clear new understanding that neurons do not work
in isolation, that they need constant interactions with other brain components
to process information, and that they are not the only information processing
system in the brain.
The Neurophysics of Human Behavior: Explorations at the Interface of the
Brain, Mind, Behavior, and Information
Mark E Furman, Fred P Gallo
CSC - Scientific Computing Ltd., Finland; 2000; pp376; ISBN: 849313082
Provides a succinct discussion of Neuro-Linguistic Programming, a method
of modeling human excellence and creating behavioral change
Discusses methods for intervention, modeling, therapeutic change, and
their neurophysical/biophysical effects on brain, mind, and behavior
Outlines NeuroPrint - a ten step algorithm for modeling cognitive-neurodynamics
Covers the neurocortical dynamics of tools of intervention to allow for
greater precision
Includes an extensive, detailed glossary of neurophysics, and related
neuroscience terminology
How do brain, mind, matter, and energy interact? Can we create a comprehensive
model of the mind and brain, their interactions, and their influences? Synthesizing
research from neuroscience, physics, biology, systems science, information
science, psychology, and the cognitive sciences, The Neurophysics of Human
Behavior advances a unified theory of brain, mind, behavior and information.
This groundbreaking work helps you more deeply understand, more accurately
predict, and more effectively change human behavior - a significant contribution
to the fields of psychology, education, medicine, communications, and human
relations.
Cognitive neurophysics, as detailed in this work, presents an integrated
perspective of brain, mind, behavior, thoughts, and nature. The distinguished
authors emphasize the need to view psychological science - and our image
of the "self" - in the context of the physical world: matter, energy, and
natural laws. NeuroPrint is the powerful application model of this perspective.
This comprehensive, detailed algorithm defines the network of interactions
that develop brain, mind, behavior, thoughts, and emotions and redefines
the meaning of psychotherapeutic intervention. The Neurophysics of Human
Behavior gives the background, tools, and methods for intervention and modeling.
It outlines the systematic, behavioral approach of NeuroPrint, promising
to promote a deep understanding of the process of human change. Using The
Neurophysics of Human Behavior, practitioners and researchers can plot and
gauge the paths of change in neurocognitive dynamics and the improvements
in mental health.
Theoretical Neuroscience
Peter Dayan, LF Abbott
MIT Press; 2001; pp576; ISBN: 0-262-04199-5
Theoretical neuroscience provides a quantitative basis for describing what
nervous systems do, determining how they function, and uncovering the general
principles by which they operate. This text introduces the basic mathematical
and computational methods of theoretical neuroscience and presents applications
in a variety of areas including vision, sensory-motor integration, development,
learning, and memory.
The book is divided into three parts. Part I discusses the relationship
between sensory stimuli and neural responses, focusing on the representation
of information by the spiking activity of neurons. Part II discusses the modeling
of neurons and neural circuits on the basis of cellular and synaptic biophysics.
Part III analyzes the role of plasticity in development and learning. An
appendix covers the mathematical methods used, and exercises are available
on the book's Web site.
Treatment of Recurrent Depression
Ed. John F. Greden
American Psychiatric Publishing; 2001; pp214; ISBN: 1585620254
Review of Psychiatry, Volume 20
Based on powerful epidemiological data such as numbers afflicted, mortality
rates from suicide, personal and familial consequences, and skyrocketing
fiscal costs, major depressive disorder (MDD) has the sad and ignominious
distinction of being a leader among disabling disorders worldwide.
With lifetime prevalence risks of 13% for men and 21% for women, the magnitude
of this crisis cannot be understated. This hard-hitting volume focuses on
recurrences—perhaps most important among the many factors (others include
extreme underdiagnosis and undertreatment, genetic vulnerability, frequent
recurrences, severe stigma and poor adherence with maintenance treatment,
and brain tissue degenerative changes associated with recurrences and chronic
depression) that contribute to MDD’s high morbidity.
Following an introduction by the editor detailing the overwhelming personal
and societal burden created by MDD, the distinguished authors of this volume
emphasize five critical topics:
The lifetime impact of gender on recurrent MDD in women, emphasizing
the clinical features, treatment, and prevention strategies of the illness
during three key periods of hormone transition (adolescence, childbearing
years, and middle life) and including recommendations on where future research
should focus.
Treatment strategies for chronic and recurrent depression to help prevent
acute episodes from developing into long-term depression, specifically addressing
the continuing question of whether pharmacotherapy and psychotherapy combinations
are superior to either alone.
Prevention of recurrences in bipolar patients, updating the demonstrated
benefits of several new anticonvulsant mood stabilizers and integrative
treatment approaches and suggesting that treatment success depends on a
multifaceted approach that combines old and new pharmacotherapy.
Potential applications of new somatic treatment strategies involving
minimally invasive brain stimulation that have greatly reduced the stigma
but done little to advance the diagnosis and treatment of neuropsychiatric
illnesses, with exciting data suggesting the efficacy of vagal nerve stimulation
(VNS) and repetitive transcranial magnetic stimulation (TMS).
A “call to arms” with updated recommendations on how to ensure demonstrable,
lasting progress in preventing recurrences of depression, which—along with
other chronic diseases such as diabetes, heart disease, and schizophrenia—progresses
throughout life unless actively treated.This highly informative volume,
clearly written and exceptionally well referenced, is a “must-read” for
every clinician, including specialists in depression and clinical neurosciences,
primary care physicians and mental health clinicians interested in learning
more about how to successfully treat what remains one of our most recalcitrant,
debilitating illnesses.
Wiley Encyclopedia of Molecular Medicine, Volumes 1-5
Edited by John Wiley & Sons, Inc.
John Wiley & Sons; 2002; pp3768; ISBN: 0471374946
The field of molecular biology is revolutionizing human medicine and the
applications of molecular biology to medicine are expanding. This encyclopedia
brings together those aspects of medicine that have significance at the
molecular level, plus advances in molecular biology that are relevant to
medicine. With over 1,700 separate primary entries, this comprehensive encyclopedia
sets the standard for reference works in this rapidly expanding field. The
coverage in this encyclopedia is multilayered, ranging from the organ to
the cell to the molecular and includes extensive cross-referencing. Geneticists,
biochemists, molecular biologists, medical researchers, and doctors with
either an academic or industrial background will find this an essential resource.
бета-Карболины. Химия и нейробиология
Дуленко В.И., Комиссаров И.В., Долженко А.Т., Николюкин Ю.Л.
Наук. думка; 1992; 216с.; ISBN 5120031188
В монографии обобщены данные по синтезу и превращениям b-карболинов и их
1,2,3,4-тетра- и 3,4-дигидропроиэводных. Приведены методики получения конкретных
соединений. Рассмотрены современные представления о b-карболинах как лигандах
бенздиазепиновых и других мембранных рецепторов нервных клеток. Анализируется
их влияние на регуляцию уровня тревожности, судорожного порога мозга, настроения,
формирования алкогольной мотивации и зависимости.
Для специалистов в области химии гетероциклических соединений, физиологически
активных веществ, а также нейрофизиологов, нейрохимиков, фармакологов и
патофизиологов.
Введение в нейрогенетику
Корочкин Л.И., Михайлов А.Т.
Наука; 2000; pp274; ISBN: 5020043045
Книга посвящена актуальным проблемам современной нейрогенетики. Авторы
рассматривают нейронную теорию как основу нейробиологии и нейрогенетики
и на базе этой теории дают подробный анализ различных аспектов этих наук.
Подробно описаны генетические системы, которые определяют выбор клеткой пути
развития и характер дифференцировки нейронов. Рассмотрены различные экспериментальные
модели, используемые в нейрогенетике и генетике поведения, и теории, которые
появились в ходе анализа результатов, полученных при исследовании этих моделей.
Для специалистов разных областей биологии и генетики, аспирантов и студентов,
занимающихся нейробиологией и нейрогенетикой.
Внутриклеточная сигнализация. Учебное пособие.
Зинченко В.П., Долгачева Л.П.
Пущино, 2003
Пособие составлено на основе курса лекций по внутриклеточной сигнализации
читаемый авторами в Пущ.ГУ
Левый мозг, правый, мозг
Спрингер С, Дейч Г.
Мир; 1983; pp256
Книга американских авторов посвящена различным аспектам функциональной
асимметрии правого и левого полушарий головного мозга человека и животных.
Рассмотрены также половые различия в характере функциональных асимметрий,
роль последних в возникновении нарушений высшей нервной деятельности, а
также связь работы правого и левого полушарий с процессами мышления и эмоциями.
Предназначена для физиологов, нейрофизиологов, психологов, психиатров и
врачей других специальностей.
Международная статистическая классификация болезней и причин, связанных
со здоровьем (10-й пересмотр) [МКБ-10]
Московский центр ВОЗ по международной классификации болезней
1999; pp741
Краткий вариант, основанный на Международной статистической классификации
болезней и проблем, связанных со здоровьем, 10-го пересмотра, принятой 43-ей
Всемирной Ассамблеей Здравоохранения
АДАПТИРОВАННЫЙ ВАРИАНТ: Подготовлен в отделе медицинской демографии и Международной
классификации болезней НИИ социальной гигиены, экономики и управления здравоохранением
им. Н.А. Семашко РАМН Введен в действие приказом Минздрава Российской Федерации
от 27.05.97 N 170. Дата введения: 01.01.99 г.
Нейробиология: в 2-х т. Т.1
Шеперд Г.
Мир; 1987; pp454
Книга американского ученого — один из первых учебников нейробиологии, представляющий
эту область знаний в широком контексте — эволюционном, клеточном, поведенческом
и историческом. На русском языке книга выходит в двух томах. В т. 1 описаны
основы сравнительной физиологии нервных клеток и организации нервных и сенсорных
систем у беспозвоночных и позвоночных.
Предназначена для специалистов по нейрофизиологии, физиологии высшей нервной
деятельности, этологов, психологов, а также студентов и преподавателей биологических
факультетов.
Нейробиология: в 2-х т. Т.2
Шеперд Г.
Мир; 1987; pp368
Книга американского ученого — один из первых учебников нейробиологии, представляющий
эту область знаний в широком контексте — эволюционном, клеточном, поведенческом
и историческом. На русском языке книга выходит в двух томах. В т. 2 на примере
животных, стоящих на разных ступенях эволюционного развития, и человека
рассмотрены двигательные функции (включая локомоцию и различные формы поведения)
и функции центральных систем (эмоции, память, научение).
Для специалистов по нейрофизиологии, физиологии высшей нервной деятельности,
этологов, психологов, а также студентов и преподавателей биологических факультетов.
Нейрохимия
Под ред. И.П. Ашмарина
Изд. Института биомедицинской химии; 1996; pp470; ISBN: 5900760022
В книге изложены основные разделы биохимии нервной системы. Рассматриваются
состав, энергетические пластические процессы, биохимия синапсов, нейромедиаторов,
нейропептидов, электрохимические процессы, функциональная биохимия отделов
мозга и нервных проводников, биохимия памяти, элементы нейрохимии патологических
состояний мозга.
Нейрохимия
Под ред. М.И.Прохоровой
Изд. Ленингр. ун-та; 1979; pp267
В основу учебного пособия положен курс лекций по нейрохимии, читаемый авторами
на кафедре биохимии Ленинградского университета. В данном пособии изложены
основные вопросы нейрохимии: характерные особенности биохимии нервной системы
и методы, используемые для её исследования; рассмотрен состав и метаболизм
белков, аминокислот, липидов нервной ткани; обсуждаются особенности регуляции
энергетического метаболизма мозга, основы нейрологической памяти и действие
нейромедиаторов.
Книга рассчитана на студентов и аспирантов-биохимиков, а также может быть
полезна биофизикам, физиологам и другим специалистам.
Нейрохимия: Основы и принципы
Хухо Ф.
Мир; 1990; 384с.; ISBN 5030010300
Учебное пособие автора из ФРГ, в котором обобщены современные представления
о нейрохимических процессах, лежащих в основе функциональной деятельности
нервной системы. Обсуждаются вопросы, касающиеся связи нейрохимии с развитием
таких смежных дисциплин, как нейрофизиология, нейрофармакология, нейроэндокринология.
Впервые приводятся данные об использовании генетических подходов в нейрохимии.
Для студентов и преподавателей университетов и медицинских вузов, а также
для биохимиков, фармакологов, врачей, специалистов в области молекулярной
биологии.
Основы нейрофизиологии: Учебное пособие
Шульговский В.В.
Аспект Пресс; 2000; pp277; ISBN: 5756701346
В книге изложены современные представления о функции клеток и нервной регуляции,
а также о комплексной иерархической регуляции основных видов деятельности
организма. В основу книги положены курсы лекций, прочитанных автором в течение
ряда лет в МГУ им. М. В. Ломоносова и Гуманитарном институте.
Для студентов, аспирантов педагогических и гуманитарных университетов.
От нейрона к мозгу
MS Word вариант
Николлс Джон, Мартин Роберт, Валлас Брюс, Фукс Пол
Едиториал УРСС; 2003; pp672; ISBN: 5354001625
Цель нового издания знаменитой и ставшей классической в нейробиологии книги
«От нейрона к мозгу» осталась той же, что и в первом издании, написанном
25 лет назад. В предисловии к этой книге цель декларирована как: «описать
способы передачи сигналов нервными клетками, как сигналы анализируются и
как на основе этой интеграции возникают высшие функции мозга. Книга предназначена
читателю без специального образования, который интересуется принципами работы
нервной системы». В новом издании четыре широко известных нейробиолога в
том же ясном стиле описывают существующие факты, методические подходы и концепции,
делая упор на экспериментальные данные, как классические, так и самые современные.
Фактически более чем на три четверти это совершенно новая книга, так как
бурный рост науки о мозге привел к удивительным открытиям в последние десятилетия.
Книга снабжена огромным количеством иллюстраций, просто и четко излагаются
не только каждая проблема, но и откуда она появилась, как связана с другими
вопросами нейробиологии. Очень приятной особенностью книги является то, что
авторы не опускают спорные вопросы, четко описывают альтернативные точки
зрения и не стесняются сказать, что многие основные проблемы в настоящее время
не решены.
Первое издание книги было переведено и стало настольным справочником по
основным вопросам физиологии мозга для нескольких поколений русскоязычных
исследователей. Первое издание входит как рекомендованная литература практически
во все курсы, касающиеся работы мозга, для студентов медицинских и биологических
вузов России. Надеемся, что новое полностью переработанное современное издание
займет такое же место.
Психогенетика
Под ред. И. В. Равич-Щербо
Аспект Пресс; 2000; pp447; ISBN: 5756702326
Первый на русском языке учебник по психогенетике для студентов университетов
и пединститутов. В доступной и систематизированной форме излагаются необходимые
базовые сведения по общей генетике, эмпирическим и математическим методам
современной психогенетики, соотношению генетических и средовых детерминант
в межиндивидуальной вариативности когнитивных функций, динамических характеристик
психики и движений, психофизиологических признаков, в нормальном и отклоняющемся
индивидуальном развитии. Коротко излагается история психогенетики за рубежом
и в России. В приложении дана программа курса лекций по психогенетике.
УДК: Структура, биология, медицина